Fort Lauderdale can be very safe but there are some parts of town you should probably avoid if you are on foot at night. Like all cities, you should ask advice on what areas are safe and what to avoid. The areas likely to be frequented by the tourists, along the beach, shopping along Las Olas and down town are safe. This would be the NE and SE parts of the city. You should use more caution if the address is on the West side of the city NW or SW. The intersection of Andrews Ave and Broward Blvd designates the NW NE SW SE sections of the city. Avoid the NW and SW areas, especially at night. The central part of Broward County West of Andrews Ave to the florida turnpike is not a place for tourists. Suburban cities that should be avoided include Lauderdale Lakes, Lauderhill and especially Sistrunk.
Rental cars stand out as obvious targets for thieves, so never leave valuables in a visible place (put any purchases or valuables in the trunk) and always lock your car doors.
Tourists may find South Florida drivers get impatient with the heavy traffic during high season. Try to plan your route before setting off and remember that US1 tunnels under Las Olas Blvd and the river. It may look like the two intersect on a map but they don't. South Florida has quite a few senior citizens on the road mixed in with their crazy teenaged offspring, so be alert.
Emergency telephone number for fire, police and rescue emergencies is 911.