How to get out Tupiza
There are several tour agents offering the four day trip to the Salar de Uyuni finishing in Uyuni. Make sure you are well acclimatized if you're doing the trip this way, since you'll go from about 3000 to 4200 m, climbing 1200 meters in just a few hours.
Furthermore there usually are daily busses to
Villazon (3-4 hours, 15 Bs.)
Potosi (6-7 hours, 40-50 Bs.)
Uyuni (5-6 hours)
La Paz (Bolivia) (80Bs)
And more destinations. Ask around at the bus station for those. Not all busses leave daily because there aren't enough people to fill the bus.
There are trains to both Villazon and Uyuni every other day. Last but not least, you can take a (shared) taxi to Villazon (3 hours, Bs. 25) or Uyuni (5-6 hours).
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The Most Frequently Asked Travel Questions about Tupiza