From Istanbul - you can either take D100 or O-4/E80 (motorway/toll-road) east to Izmit, then head west there along the southern shore of the Gulf of İzmit to Yalova, or take a ferry -which can accommodate cars- to Yalova. Once in Yalova, take D575/E881 highway south to Bursa. After about 30-40 km away from Yalova, you'll arrive in Orhangazi. At Orhangazi, you'll notice the junction of the secondary road lying on the northern shore of Lake İznik (there are İznik/Nicaea signs). From that junction, İznik is about a 30-40 min drive away.
If you choose not to take a ferry to Yalova, you also have the option of taking the mountainous road which forks from the main highway about 5 km west of Karamürsel. This road is shorter than the above route, but curvier.
From Bursa - Take D575/E881 highway north to Yalova. Somewhere between Gemlik and Orhangazi, you'll come across a junction with traffic lights. On that junction, you'll notice İznik/Nicaea signs. That road will take you to İznik along the southern shore of the lake in about 30-40 minutes.
The Most Frequently Asked Travel Questions about Iznik
Where To Stay & Best Hotels in Iznik - updated May 2024
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Iznik Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.