The high mountains pose the usual mountain hazards (altitude sickness and avalanche danger for the hiker/skier, snowpacked roads in the winter for the motorist). Roads here are also plagued by drunk drivers; drive suspiciously, particularly after dark.
There are few significant public-health issues in this region of concern to the traveler, but curiously enough, bubonic plague (the real thing, not the DUI "plague") is endemic, and claims a few victims each year (most recover with prompt and aggressive medical care). Plague is carried by the small animals of the region, so if you see one in distress, leave it alone and let nature take its course; buzzards are immune to plague, you are not. Drinking untreated water from regional streams is not a good idea owing to Giardia parasites, but tap water is generally not a problem.
One other note: avoid small-town bars here unless you're with someone well known in the bar. Some have clienteles that don't take kindly to strangers.
The Most Frequently Asked Travel Questions about North Central New Mexico
Where To Stay & Best Hotels in North Central New Mexico - updated May 2024
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North Central New Mexico Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.