San Angelo is not on an Interstate highway, so there aren't any completely direct routes from any major cities.
From the Dallas/Fort Worth area, take Interstate 20 to Abilene, and then either US-277 directly to San Angelo, or US-83 to Ballinger and US-67 from there to San Angelo (neither route is substantially faster or slower).
From San Antonio, the best path is probably Interstate 10 to Fredericksburg, US-83 to Eden, then US-87 to San Angelo.
From El Paso one can start on Interstate 10, then get onto Interstate 20 when it splits off from 10, go through Midland and Odessa to Big Spring, and then take US-87 from there to San Angelo.
The Most Frequently Asked Travel Questions about San Angelo
Where To Stay & Best Hotels in San Angelo - updated May 2024
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San Angelo Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.