I-77 runs north-west through this region.
I-70 runs east-west along the northern portion of the region.
If you wish to ferry across the Ohio River, there are three remaining commercial passenger ferries, Monroe County at Fly, to to Sisterville, West Virginia - Higginsport, Ohio in Brown County to Augusta, Kentucky - Cincinnati, Ohio to Constance, Kentucky. All-year, continous daily service, weather permitting. Car=about $3 or less.
The Most Frequently Asked Travel Questions about Southeast Ohio
Where To Stay & Best Hotels in Southeast Ohio - updated Apr 2024
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Southeast Ohio Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.