The most scenic route from the lower peninsula would be US-31 along the coast of Lake Michigan over the Mackinac (pronounced mack-in-aw) Bridge and through St. Ignace.
Access from Wisconsin is most common through US-45 (central), US-141 (central-eastern), US-41 (far eastern) or US-2 (western). US-41 and US-2 are probably the most scenic choices.
The Most Frequently Asked Travel Questions about Upper Peninsula
Where To Stay & Best Hotels in Upper Peninsula - updated May 2024
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Upper Peninsula Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.